Programa de Pós-Graduação em Inovação Terapêutica (PPGIT)
Curriculum Grid Curriculum Grid
- Mandatory subjects
1. Mandatory subjects:
Subject: Innovation in Health
Code: PIT-900
Workload: 45 hours
Credits: 03
Professor (s): César Augusto Souza de Andrade and José Lamartine Soares Sobrinho.
Objectives: To promote an understanding of the technological innovation process in general, and in the fields of health, in particular; b) Understand the role of technological innovation in the context of globalization of markets; c) Discuss techniques and instruments through which the innovation process can be promoted and managed by the company, the state, and the university; e) Sensitize participants to the importance of articulation and cooperation from different fields of knowledge for the development of innovation, in general, and innovation in health, in particular.
Subject: Scientific Method
Code: PIT-901
Workload: 45 hours
Credits: 03
Professor: Maria Danielly Lima de Oliveira e Giselia Alves Pontes da Silva
Objectives: To enable the student to carry out a bibliographic search, instructing him in the use of procedures and techniques for searching and retrieving information, both manual and computerized, and in the presentation of a final research report, to: Instruct graduate students in the use of general and specialized information sources, both manual and automated; Prepare students for reading technical and scientific texts; Train students to apply the ABNT rules on documentation; Offer students subsidies for conducting a bibliographic search; Guide students in presenting a final research report.
Subject: Computational Methods in Therapeutic Innovation
Code: PIT-902
Workload: 45 hours
Credits: 03
Professor: Marcelo Zaldini Hernandes
Objectives: Therapeutic Innovation (IT) is a broad concept, related to the area of ¿¿science called Medicinal Chemistry, which in turn deals with the discovery, development, identification, and interpretation of the mode of action of biologically active compounds, as well as with the study, identification and synthesis of the metabolic products of drugs and related products. This course aims to show students the potential of applying computational methods within this area of ¿¿interest, in addition to providing a methodological basis on the use of computers in the most diverse aspects related to Therapeutic Innovation. As the focus is trans and multi-disciplinary, the objective of this discipline is also to guide or guide students' learning towards the specific knowledge they need to acquire in the field of computational tools that will be useful for the optimized development of their specific work of dissertation or thesis.
Subject: Seminars on Therapeutic Innovation
Code: PIT-903
Workload: 45 hours
Credits: 03
Professor (s): Maira Galdino da Rocha Pitta and César Augusto Souza de Andrade.
Objectives: Within the scope of themes related to technological innovation, current issues related to research projects developed by graduate students, teachers, and visitors will be prioritized. The course will provide an opportunity for interaction between the lines of research included in the Program, including the contribution of invited external experts.
- Elective courses
2. Elective courses:
Subject: Special Activities
Code: PIT-904
Workload: 15 hours
Credits: 01
Professor: César Augusto Souza de Andrade
Objectives: According to the work that is being followed, corresponding to special activities developed by the student, credited in line with the program's supervisor and coordination, such as monitoring of undergraduate students; organization of events and other activities of interest to the Program; sandwich stage; presentation of works in events of international repercussion, among other.
Subject: Nanostructured Biodevices
Code: PIT-906
Workload: 45 hours
Credits: 03
Professor: César Augusto Souza de Andrade
Objectives: Within the scope of nanobiotechnology, the course aims to introduce the student to a multi and interdisciplinary approach of theoretical concepts and experimental techniques for the characterization of pharmaceutical products and the generation of bio-devices on a nanometric scale. The discipline conceptualizes the physical-chemical bases that guide the obtaining of structured ultrathin films (Langmuir and Langmuir-Blodgett films), self-assembly (self-assembly), and colloidal systems (synthesis of nanoparticles, nanospheres, micelles, reverse micelles, vesicles, and liposomes ). These studies aim at the generation of technological products for diagnostic purposes (biological nanosensors) and their applications in the pharmaceutical industry, with a critical reflection on their uses in scientific research. Finally, we will study the techniques for characterizing nanosystems
Subject: Biomarkers
Code: PIT-905
Workload: 60 hours
Credits: 04
Professor (s): Moacyr Jesus Barreto de Melo Rêgo
Objectives: The diagnosis, prognosis and development and targeting of new drugs use biomarkers. These biological tools, combined with peroxidase, fluorescein isothiocyanate, artificial fluorescent compounds (acridine ester, cryptates), have been used in medical and veterinary research and diagnosis. Among them we highlight the immuno (histo) cytochemistry and histochemistry with lectins. These techniques, in many cases, are fundamental in the differential diagnosis, contributing greatly to the therapy to be administered to the patient.
Subject: Canalopathies
Code: PIT-907
Workload: 45 hours
Credits: 03
Professor: Claudio Gabriel Rodrigues
Objectives: To enable the learning of the various methods and techniques for the study of ion channels, correlating them with the development of new drugs and the mechanism of the molecular action of drugs.
Subject: Contemporary Capitalism and the Pharmaceutical Industry
Code: PIT-908
Workload: 45 hours
Credits: 03
Professor: João Policarpo Rodrigues Lima
Objectives: Globalization: Conditions and Transformations in Progress; The new technological paradigm; Trends in the integration and globalization of productive activities; Deregulation of financial markets; The new context and the Economic Blocks; The industrial sector and the ongoing transformations; General trends in the pharmaceutical industry. The trends of the pharmaceutical industry in Brazil; Pernambuco and the pharmaceutical pole under construction. The medical pole of Pernambuco: potential and challenges.
Subject: Capitalism and Health - Recent History and Main Trends
Code: PIT-909
Workload: 60 hours
Credits: 04
Professor: João Policarpo Rodrigues Lima
Objectives: The objective of this course is to provide a sociological, political and cultural understanding of health as it presents itself and transforms itself in the last two centuries in capitalist society
Subject: Design and Development of Drugs and Medicines
Code: PIT-910
Workload: 60 hours
Credits: 04
Professor: Ana Cristina Lima Leite
Objectives: To provide students with the opportunity to understand modern strategies for the discovery and development of new drugs.
Subject: Development of Pharmaceutical Forms
Code: PIT-911
Workload: 60 hours
Credits: 04
Professor: Pedro Rolim
Objectives: Application of technological resources and concepts related to the study of pre-formulation of pharmaceutical forms, including rational planning: from the drug to the medication. Approach to physical facilities, machinery, processes, and legislation relevant to product licensing for the pharmaceutical industry.
Subject: Teaching Internship
Code: PIT-912
Workload: 30 hours
Credits: 02
Professor: César Augusto Souza de Andrade and Maira Galdino da Rocha Pitta
Objectives: Participation of graduate students in undergraduate teaching activities, under the supervision of the supervisor and with the presence of the professor responsible for the discipline.
Subject: Applied Statistics
Code: PIT-913
Workload: 45 hours
Credits: 03
Professor: Tatiane Almeida de Menezes.
Objectives: To provide the student with the opportunity to apply statistical tools to a real situation. Develop counting system
Subject: Stereochemistry of Bioactive Molecules
Code: PIT-914
Workload: 45 hours
Credits: 03
Professor: Ivan da Rocha Pitta.
Objectives: The course aims to provide students with the visualization of the three-dimensional structure of drugs and biologically active molecules, and the dependence of this structure to produce biological effects.
Subject: Pharmacokinetics: from fundamental to applied
Code: PIT-915
Workload: 60 hours
Credits: 04
Professor: César Augusto Souza de Andrade
Objectives: The Pharmacokinetic discipline: from fundamental to applied, aims to provide graduate students with advanced theoretical and practical knowledge of drugs with regard to qualitative (absorption, distribution and elimination) and quantitative pharmacokinetic aspects (mathematical notions of linear and non-linear kinetics, parameter calculations and pharmacokinetic models); thus providing subsidies for the development and evaluation of new molecules, drugs and pharmaceutical forms.
Subject: Pharmacogenomics
Code: PIT-916
Workload: 45 hours
Credits: 03
Professor: Maira Galdino da Rocha Pitta
Objectives: In the context of the interdisciplinarity of pharmacology, genetics and medicine, the Pharmacogenomics discipline offers students the opportunity to have knowledge about the application of new technologies - such as DNA sequencing and analysis of gene expression - in research for the discovery and development of drugs , and in clinical trials of drugs, by identifying genes that would be involved in determining a particular pharmacological response.
Subject: Pharmacology and Therapeutics of Prevalent Diseases
Code: PIT-917
Workload: 60 hours
Credits: 04
Professor: Maria Carolina Accioly Brelaz de Castro
Objectives: To train students with knowledge, skills and attitudes that enable them to deepen their knowledge, with an emphasis on the cardiovascular and renal systems and in the identification of the broad classes of drugs used in cardiovascular diseases, chronic renal failure and diabetic nephropathy. Such knowledge will allow better interaction with the patient and better conditions to provide pharmaceutical care guided by the rational application of medicines, as well as allowing reflections on the modern techniques used as new therapeutic strategies.
Subject: Spectrometric Identification of Bioactive Compounds I: Ultraviolet and Infrared
Code: PIT-918
Workload: 45 hours
Credits: 03
Professor: Maria do Carmo Alves de Lima, Francisco Jaime Bezerra Mendonça Júnior.
Objectives: To offer the student the opportunity to explore all the resources of ultraviolet and infrared as a tool for the verification and identification of molecular structures.
Subject: Spectrometric Identification of Bioactive Compounds II: Nuclear Magnetic Resonance and Mass
Code: PIT-919
Workload: 60 hours
Credits: 04
Professor: Maria do Carmo Alves de Lima, Antônio Rodolfo de Faria and Francisco Jaime Bezerra Mendonça Júnior.
Objectives: The objective of the course is to offer the student the ability to understand and deepen the use of NMR and mass spectrometry in the verification and determination of structures of organic compounds, through the analysis of spectra obtained by the different techniques covered. Know the various types of mass spectra. Learn to interpret a mass spectrum. Application of NMR spectrometry in structural analysis.
Subject: Immunology Applied to Drug Research and Development
Code: PIT-920
Workload: 45 hours
Credits: 03
Professor: Valéria Rêgo Alves Pereira.
Objectives: The objective of the course is to transmit to students the knowledge of basic and applied immunology to the study of drugs with emphasis on neglected diseases and to introduce them to the research and development of approaches used in this study.
Subject: Molecular Mechanisms of Pharmacological Interactions
Code: PIT-921
Workload: 60 hours
Credits: 04
Professor: Maira Galdino da Rocha Pitta.
Objectives: The course aims to offer the student an updated discussion of the mechanisms of cell signaling involved in the actions of various classes of drugs with an emphasis on their therapeutic relevance.
Subject: Molecular Modeling in Systems of Biological Interest
Code: PIT-922
Workload: 45 hours
Credits: 03
Professor: Marcelo Zaldini Hernandes.
Objectives: The purpose of this course is to introduce and / or deepen the student's knowledge in the aspects of Molecular Modeling of Systems of Biological Interest, through the presentation of various planning methods in silico. The student will be introduced to fundamental concepts with regard to the issues involved with intermolecular interactions and their relationship between bioactive molecules and biological targets, in addition to learning aimed at discussing the methods available for molecular planning.
Subject: Experimental Models for the Evaluation of Biological Activity
Code: PIT-923
Workload: 60 hours
Credits: 04
Professor: Teresinha Gonçalves da Silva and Paloma Lys.
Objectives: This course aims to provide the student with advanced and current knowledge about various tests used in Pharmacology, with emphasis on the methodologies used in the routine of laboratories for screening new prototypes candidates for drugs and medicines, according to the standards recommended by the regulatory agencies. Pharmacological parameters will be discussed, as well as the advantages and limitations of each methodology. Pharmacological and statistical concepts that can be visualized in these experiments will also be addressed.
Subject: Therapeutic and Diagnostic Nanosystems: A Pharmaceutical-Technological Innovation
Code: PIT-924
Workload: 60 hours
Credits: 04
Professor: César Augusto Souza de Andrade.
Objectives: The objective of the course is to transmit technological know-how and induce scientific research, working on contemporary aspects of therapy through Pharmaceutical Nanotechnology, addressing variants of nanosystems intended for the treatment of specific diseases, such as cancer, diabetes, parasites and infections in general ; as vectors in gene therapy and the modern diagnosis of human diseases.
Subject: Production of Recombinant Proteins for Pharmacological Use
Code: PIT-925
Workload: 60 hours
Credits: 04
Professor: Antônio Carlos de Freitas.
Objectives: Review of the bases of molecular biology focusing on molecular tools applied to the development of strategies for the production of recombinant proteins of pharmacological interest in different expression systems, in order to provide the student with an integrated view of the strategies applied to the production of drugs based on use of genetic engineering.
Subject: Organic Medicinal Chemistry
Code: PIT-926
Workload: 60 hours
Credits: 04
Professor: Maria do Carmo Alves de Lima.
Objectives: Organic Medicinal Chemistry has provided extraordinary advances in the discovery and development of new drugs, the evolution of which remains unbroken by the vast availability of analytical and operational instrumentation that allows the preparation of potentially bioactive functionalized original molecules. In this sense, the objective of this course is to provide the student with training on all the main existing methods for the preparation and purification of organic compounds, with an emphasis on molecules whose functional groups are representative in drugs.
Subject: Quantitative Relationship Activity Structure
Code: PIT-927
Workload: 60 hours
Credits: 04
Professor: Marcelo Zaldini Hernandes.
Objectives: This course aims to introduce the student to the necessary knowledge to create and evaluate a quantitative relationship between biological activity and a set of descriptive parameters, in a homologous series of molecules.
Subject: Preclinical Safety in Drug Development
Code: PIT-928
Workload: 60 hours
Credits: 04
Professor: Paloma Lys de Medeiros and Teresinha Gonçalves da Silva.
Objectives: To study strategic techniques of pre-clinical validation for the development of new drugs; reassess the activity of drugs already available on the market.
Subject: Theory and Sociology of Legal Protection of Intellectual Property
Code: PIT-929
Workload: 60 hours
Credits: 04
Professor: Moacyr Jesus Barreto de Melo Rêgo.
Objectives: To encourage the production of reflections on intellectual property in products in the pharmaceutical chain, as well as assist in the preparation of dissertations and theses aimed at intellectual property in the area of ¿¿pharmaceuticals, medications and essential health supplies. In this sense, the discipline is focused on the debate and research on the legal dimension of intellectual property, which involves addressing the concepts, institutes and legal-social aspects. Among the concepts will be works: the Legal Norm Theory: structure, characteristics, legitimacy, validity, validity and effectiveness; legal relationship, legal business, mandatory relationship, validity and effectiveness of contracts; Legal Hermeneutics: the problem of interpretation, limit and decision-making power in the legal sphere. Among the legal institutes will be worked: law of obligations, contract; contractual legal liability. Intellectual property: legal protection; legal instruments for the protection of intellectual property; national and international bodies and intellectual property; biotechnology and intellectual property.
Subject: Territory and Technological Innovation
Code: PIT-930
Workload: 45 hours
Credits: 03
Professor: César Augusto Souza de Andrade and José Lamartine Soares Sobrinho.
Objectives: Understanding the conceptual elements of the production process of regions under capitalism, recent dynamics and the spatial configuration of contemporary capitalism and the territorial impacts of innovative dynamics, with an emphasis on Brazil.
Subject: Advanced Topics in Therapeutic Innovation
Code: PIT-931
Workload: 60 hours
Credits: 04
Professor: César Augusto Andrade and Luiz Alberto Lira Soares.
Objectives: Variable study program, from semester to semester, aiming to meet the interests of students and teachers, in current themes and with emphasis on the lines and research projects of the Program. The courses taught are intended to foster the teaching, research and extension dynamics planned by the Program. This discipline also allows the revalidation of credits obtained in other stricto sensu Graduate Programs recommended by CAPES for the payment of the student's workload, observing the PPGIT Internal Regulations.
Subject: Advanced Topics in Therapeutic Innovation II
Code: PIT-932
Workload: 45 hours
Credits: 03
Pprofessor: Maira Galdino da Rocha Pitta and Karina Perrelli Randau.
Objectives: Variable study program, from semester to semester, aiming to meet the interests of students and teachers, in current themes and with emphasis on the lines and research projects of the Program. The courses taught are intended to foster the teaching, research and extension dynamics planned by the Program. This discipline also allows the revalidation of credits obtained in other stricto sensu Graduate Programs recommended by CAPES for the payment of the student's workload, observing the PPGIT Internal Regulations.
Subject: Advanced Topics in Therapeutic Innovation III
Code: PIT-933
Workload: 30 hours
Credits: 02
Professor: Dinaldo Cavalcanti de Oliveira and Mônica Felts de La Roca Soares.
Objectives: Variable study program, from semester to semester, aiming to meet the interests of students and teachers, in current themes and with emphasis on the lines and research projects of the Program. The courses taught are intended to foster the teaching, research and extension dynamics planned by the Program. This discipline also allows the revalidation of credits obtained in other stricto sensu Graduate Programs recommended by CAPES for the payment of the student's workload, observing the PPGIT Internal Regulations.
Subject: Advanced Topics in Therapeutic Innovation IV
Code: PIT-934
Workload: 15 hours
Credits: 01
Professor: Maira Galdino da Rocha Pitta.
Objectives: Variable study program, from semester to semester, aiming to meet the interests of students and teachers, in current themes and with emphasis on the lines and research projects of the Program. The courses taught are intended to foster the teaching, research and extension dynamics planned by the Program. This discipline also allows the revalidation of credits obtained in other stricto sensu Graduate Programs recommended by CAPES for the payment of the student's workload, observing the PPGIT Internal Regulations.
Subject: Special Activities II
Code: PIT-935
Workload: 30 hours
Credits: 02
Professor: César Augusto Souza de Andrade
Objectives: According to the work that is being followed, corresponding to special activities developed by the student, credited in line with the program's supervisor and coordination, such as: monitoring of undergraduate students; organization of events and other activities of interest to the Program; sandwich stage; presentation of works in events of international repercussion, among others.
Subject: Translational Research
Code: PIT-936
Workload: 45 hours
Credits: 03
Professor: Dinaldo Cavalcanti de Oliveira
Objectives: Qualified training for the development of Translational Research.
Subject: Health Education
Code: PIT-937
Hours: 60 hours (30P / 30T)
Credits: 04
Professor: Bruno Severo Gomes and Maira Galdino da Rocha Pitta
Objectives: In criticizing the utilitarian sanitary model focused on changing individual behaviors and on medical-centered assistance, the Health Education Discipline aims to introduce students to social participation in the definition and search for solutions to health problems, as well as control over health. the actions developed by the institutions. It advocates changes in the social structure, emphasizing the necessary education of the population for both